The safety of our food supply is an important public concern, whether the food is derived from conventional methods, organic production, or biotechnology. The assessment of the safety of genetically engineered (GE) organisms, in particular, in our food supply is critical. The available scientific evidence suggests that the biotechnology currently used in genetically engineered organisms does not present food safety issues that differ from traditional agricultural or breeding practices. Furthermore, there is no verifiable scientific evidence that consumption of a GE organism has resulted in adverse health effects. This paper explores questions related to food safety and regulations for GE organisms in agriculture.